Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity
نویسندگان
چکیده
منابع مشابه
moz regulates Hox expression and pharyngeal segmental identity in zebrafish.
In vertebrate embryos, streams of cranial neural crest (CNC) cells migrate to form segmental pharyngeal arches and differentiate into segment-specific parts of the facial skeleton. To identify genes involved in specifying segmental identity in the vertebrate head, we screened for mutations affecting cartilage patterning in the zebrafish larval pharynx. We present the positional cloning and init...
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Development of the facial skeleton depends on interactions between intrinsic factors in the skeletal precursors and extrinsic signals in the facial environment. Hox genes have been proposed to act cell-intrinsically in skeletogenic cranial neural crest cells (CNC) for skeletal pattern. However, Hox genes are also expressed in other facial tissues, such as the ectoderm and endoderm, suggesting t...
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Retinoids have long been recognized as teratogens for vertebrate embryos with effects on a wide variety of structures at a number of stages of development (Hale, 1933; Cohlan, 1953; Shenefelt, 1972). The responding organ or structure typically has a period of sensitivity to exogenous retinoids that corresponds approximately to the time of establishment of the anlage for that organ or structure ...
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Involucrin is a major component of the cornified envelope and a marker for terminal differentiation in keratinocytes. We examined hormone regulation of involucrin mRNA expression and transcriptional modulation of the involucrin gene in human keratinocyte cell lines. Dexamethasone enhanced, and retinoic acid decreased, endogenous involucrin mRNA expression in cells treated with these ligands. Fu...
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Many animal body plans are constructed of serially repeated structures that develop from initially equivalent fields of cells during embryogenesis. Serially homologous structures often attain different morphologies and functions within a single animal and changes in their number, form and function mark many important evolutionary differences between taxa (Carroll et al., 2001). Understanding th...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2009
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2009.10.006